Request Specimens

A critical component of PPMI is the standardized, longitudinal collection of biospecimens, which include plasma, serum, blood, cerebrospinal fluid (CSF), DNA and RNA. Regular longitudinal collection of peripheral mononuclear blood cells (PBMCs) has also been integrated into the regular schedule of activities for all PPMI subjects. An inventory of the biospecimens is available through the PPMI database and can reviewed by investigators interested in incorporating PPMI samples in their research. PPMI samples can only be used for biomarker verification studies.  If you are interested in requesting biospecimens for other biomarker research, please view our complementary resources.

The table below is an inventory of the number and type of biospecimen samples collected and currently available for analysis.

PBMC Inventory

Click here to download PPMI PBMC Isolation Overview.

Application Process to Request Specimens

Click below to read more about the process for accessing banked specimens and to begin the request process.Researchers requesting specimens must agree to the Biospecimen Use Agreement and the Publications Policy.

Before starting the specimen request process, click here to download a template for the Pre-Proposal.

Research Funding for Specimen Studies

Researchers requesting biospecimens may also apply for funding from The Michael J. Fox Foundation (MJFF). The review processes for PPMI biospecimen access and MJFF funding of research are separate processes; approval for use of PPMI biospecimens does not guarantee MJFF funding. MJFF has identified Biomarkers as a priority funding area and will consider proposals from researchers who have been granted PPMI samples. Investigators interested in requesting funding from MJFF should indicate that in their Pre-Proposal.

Ongoing Specimen Analyses and Other Resources

A listing of preliminary analyses specified by the Steering Committee and performed by PPMI cores, as well as analyses performed by additional investigators are listed in the ongoing analyses section of this site. Investigators who are granted samples from PPMI agree to update this information annually, providing the research public with a comprehensive list of the latest findings coming out of PPMI.

Researchers who are interested in reviewing the PPMI collection, processing and storage protocols for biospecimens should review the Biologics Manual, found with the Research Documents and SOPs.

.
Months ScBL369121824303642485460728496
Biospecimens
CSF129585049794806361914642363791406
DNA130711193055741621514686554583625650558535269315176
RNA119076921185624128011601239956880799749612591299337188
Plasma119176931185631128211601240953884797746612590300336188
Serum119106921190628127911541234950877793741603589299331187
Urine425466133224731373643131422519027
Whole blood117395901116568121111091184913848781739610589297331185
Months BL 6 18 30 42 54 72 84 96 108 120 132 144 156
PBMC Inventory
PD - - - - 6 83 43 109 77 12 - - - -
Control - - - - 6 23 10 18 58 12 - - - -
SWEDD - - - - - - - 1 3 - - - - -
Prodromal - - - 35 47 33 6 - - - - - - -
Genetic PD 50 96 96 92 69 55 - - - - - - - -
Genetic Unaffected 74 217 163 134 84 24 - - - - - - - -