Study Cohorts

The following groups of subjects are being followed in the PPMI study.

De Novo PD Subjects

Subjects with a diagnosis of PD for two years or less who are not taking PD medications.

Enrollment Goal: 400 Actual Enrollment: 423 Completed April 2013
Months ScBL369121824303642485460728496
Participants47243039028733836537236436336235333123915534

Control Subjects

Control Subjects without PD who are 30 years or older and who do not have a first degree blood relative with PD.

Enrollment Goal: 200 Actual Enrollment: 196 Completed April 2013
Months ScBL369121824303642485460728496
Participants235198190184181185178174165167166157129122

Subjects with Scans without Evidence of a Dopaminergic Deficit (SWEDD)

Subjects consented as PD subjects who have DaTscans that do not show evidence of a dopaminergic deficit.

Enrollment Goal: n/a Actual Enrollment: 64 Completed April 2013
Months ScBL369121824303642485460728496
Participants8166575356575856113233

Prodromal Subjects

Subjects without Parkinson's disease who have a diagnosis of hyposmia or REM sleep behavior disorder (RBD).

Enrollment Goal: 100 Actual Enrollment: 65 Completed March 2015
Months ScBL36912182430364248
Participants1876460606061615839163

Genetic Cohort Subjects

Subjects with and without Parkinson’s disease who have a genetic mutation in LRRK2, GBA, or SNCA.

Enrollment Goal: 600 Actual Enrollment: Recruiting
Months ScBL6121824303642485460
Participants1561811421098659367

Genetic Registry Subjects

Subjects with and without Parkinson’s disease who have a genetic mutation in LRRK2, GBA, or SNCA or a first-degree relative with a LRRK2, GBA, or SNCA mutation who are evaluated at less frequent intervals to augment and broaden the follow-up of PD subjects and family members with PD associated mutations .

*Phone visits

Enrollment Goal: 600 Actual Enrollment: Recruiting
Months SC/BL6*12*18*2430*36*42*4854*60*
Participants38725121