The following groups of subjects are being followed in the PPMI study.
De Novo PD Subjects
Subjects with a diagnosis of PD for two years or less who are not taking PD medications.
| Enrollment Goal: 400 | Actual Enrollment: 423 | Completed April 2013 | |||||||||||||||
| Months | Sc | BL | 3 | 6 | 9 | 12 | 18 | 24 | 30 | 36 | 42 | 48 | 54 | 60 | 72 | 84 | 96 |
| Participants | 472 | 430 | 390 | 287 | 338 | 366 | 372 | 364 | 363 | 362 | 353 | 338 | 259 | 176 | 45 | – | – |
Control Subjects
Control Subjects without PD who are 30 years or older and who do not have a first degree blood relative with PD.
| Enrollment Goal: 200 | Actual Enrollment: 196 | Completed April 2013 | |||||||||||||||
| Months | Sc | BL | 3 | 6 | 9 | 12 | 18 | 24 | 30 | 36 | 42 | 48 | 54 | 60 | 72 | 84 | 96 |
| Participants | 235 | 198 | 190 | 184 | 181 | 185 | 178 | 174 | 165 | 167 | 166 | 161 | 135 | 125 | – | – | – |
Subjects with Scans without Evidence of a Dopaminergic Deficit (SWEDD)
Subjects consented as PD subjects who have DaTscans that do not show evidence of a dopaminergic deficit.
| Enrollment Goal: n/a | Actual Enrollment: 64 | Completed April 2013 | |||||||||||||||
| Months | Sc | BL | 3 | 6 | 9 | 12 | 18 | 24 | 30 | 36 | 42 | 48 | 54 | 60 | 72 | 84 | 96 |
| Participants | 81 | 66 | 57 | 53 | 56 | 57 | 58 | 56 | 1 | 1 | 3 | 2 | 3 | 3 | 1 | – | – |
Prodromal Subjects
Subjects without Parkinson's disease who have a diagnosis of hyposmia or REM sleep behavior disorder (RBD).
| Enrollment Goal: 100 | Actual Enrollment: 65 | Completed March 2015 | ||||||||||
| Months | Sc | BL | 3 | 6 | 9 | 12 | 18 | 24 | 30 | 36 | 42 | 48 |
| Participants | 187 | 64 | 60 | 60 | 60 | 61 | 61 | 58 | 43 | 23 | 5 | – |
Genetic Cohort Subjects
Subjects with and without Parkinsons disease who have a genetic mutation in LRRK2, GBA, or SNCA.
| Enrollment Goal: 600 | Actual Enrollment: Recruiting | |||||||||||
| Months | Sc | BL | 6 | 12 | 18 | 24 | 30 | 36 | 42 | 48 | 54 | 60 |
| Participants | 158 | 187 | 149 | 119 | 91 | 68 | 51 | 23 | – | – | – | – |
Genetic Registry Subjects
Subjects with and without Parkinsons disease who have a genetic mutation in LRRK2, GBA, or SNCA or a first-degree relative with a LRRK2, GBA, or SNCA mutation who are evaluated at less frequent intervals to augment and broaden the follow-up of PD subjects and family members with PD associated mutations .
*Phone visits
| Enrollment Goal: 600 | Actual Enrollment: Recruiting | ||||||||||
| Months | SC/BL | 6* | 12* | 18* | 24 | 30* | 36* | 42* | 48 | 54* | 60* |
| Participants | 399 | – | – | 2 | 57 | 2 | 2 | – | – | – | – |
