Our Mission

The mission of PPMI is to identify one or more biomarkers of Parkinson’s disease progression. The discovery of a biomarker is a critical step in the development of new and better treatments for PD. This study is being sponsored by The Michael J. Fox Foundation for Parkinson's Research.

PPMI Enrollment Status

Prodromal Participants
Enrollment Goal: 100

Genetic Cohort Participants
Enrollmen Goal: 600

Genetic Registry Participants
Enrollment Goal: ~600

De Novo PD Participants
Enrollment Goal: 400

Control Participants
Enrollment Goal: 200

Subjects with SWEDD
Enrollment: 64

Last Update: December 16, 2014


More about study cohorts >


Welcome to the Parkinson’s Progression Markers Initiative (PPMI), a landmark observational clinical study to comprehensively evaluate cohorts of significant interest using advanced imaging, biologic sampling and clinical and behavioral assessments to identify biomarkers of Parkinson’s disease progression.

PPMI is taking place at clinical sites in the United States, Europe, Israel, and Australia. Data and samples acquired from study participants will enable the development of a comprehensive Parkinson’s database and biorepository, which is currently available to the scientific community to conduct field-changing research.

PPMI is made possible by the concerted efforts of a number of collaborators. This study is sponsored by The Michael J. Fox Foundation for Parkinson’s Research.

Learn more about Who We Are.


PPMI Biosamples Webinar Posted

PPMI’s principal investigator, Ken Marek, MD, and The Michael J. Fox Foundation’s Mark Frasier, PhD held the PPMI Progress Update: Available Data and Biosamples webinar, covering an overview of PPMI, some initial findings, and the process for accessing the PPMI clinical data, imaging data, and biospecimens. A recording of the webinar is now available.

New Serum Data Ready to Download

Serum analysis data from Maria Teresa Pellecchia, MD of the University of Salerno is now live in the PPMI database. Qualified researchers can download this data at no cost.

Webinar on Available Parkinson’s and Controls Biosamples

PPMI and The Michael J. Fox Foundation are hosting a webinar which will cover available PPMI samples and data and the process for requesting both. The webinar will take place Monday, December 15, 12 to 1 p.m. ET. Learn more and register today.

Video: Thank you from Michael J. Fox

Michael J. Fox has created an exclusive video thanking the PPMI volunteers and researchers for their exceptional contributions to Parkinson’s research.

Over 22,000 Samples Currently Available

PPMI has been actively collecting a wealth of biospecimens from the study participants, a group that has now grown to over 800 enrolled individuals. The samples are standardized, longitudinal, and available to qualified researchers conducting biomarker verification studies.

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