Our Mission

The mission of PPMI is to identify one or more biomarkers of Parkinson’s disease progression. The discovery of a biomarker is a critical step in the development of new and better treatments for PD. This study is being sponsored by The Michael J. Fox Foundation for Parkinson's Research.

PPMI Enrollment Status

Prodromal Participants
Enrollment Goal: 100

Genetic Cohort Participants
Enrollmen Goal: 600

Genetic Registry Participants
Enrollment Goal: ~600

De Novo PD Participants
Enrollment Goal: 400

Control Participants
Enrollment Goal: 200

Subjects with SWEDD
Enrollment: 64

Last Update: March 4, 2014


More about study cohorts >


Welcome to the Parkinson’s Progression Markers Initiative (PPMI), a landmark observational clinical study to comprehensively evaluate cohorts of significant interest using advanced imaging, biologic sampling and clinical and behavioral assessments to identify biomarkers of Parkinson’s disease progression.

PPMI is taking place at clinical sites in the United States, Europe, and Australia. Data and samples acquired from study participants will enable the development of a comprehensive Parkinson’s database and biorepository, which is currently available to the scientific community to conduct field-changing research.

PPMI is made possible by the concerted efforts of a number of collaborators. This study is sponsored by The Michael J. Fox Foundation for Parkinson’s Research.

Learn more about Who We Are.


New Feature: PPMI Imaging Inventory

An inventory of the available imaging from PPMI is now viewable on the Access Data & Specimens page on www.ppmi-info.org.  The inventory table is updated in real-time, providing researchers with a summary of what images are available before they submit a request for access.  The inventory table contains MRI, PET, and SPECT images broken down […]

Opportunity for Funding and Access to Data and Specimens

Using a single application, qualified researchers may request access to clinical data and biospecimens from a collection of studies exploring promising areas in Parkinson’s research, including PPMI. The Michael J. Fox Foundation for Parkinson’s Research (MJFF) is also offering funding for use and analysis of the available information and materials.  Applicants may request up to […]

Michael J. Fox Foundation Press Release Announces PPMI Genetic Cohort

In late February, a press release officially announced the launch of PPMI’s new study arm to examine the role of genetic mutations in Parkinson’s disease.  Leveraging the robust infrastructure already established in PPMI, the study expanded to enroll individuals with mutations of the LRRK2 and SNCA genes.  The expansion was reported globally by Jewish publications, […]

Important Update Regarding PPMI CSF Data

A letter from the PPMI Steering Committee regarding the status of CSF Data.

Funding Opportunity for Research in PPMI and ADNI

A new funding opportunity for research into both Parkinson’s and Alzheimer’s has been launched. The Michael J. Fox Foundation, the Alzheimer’s Association and The W. Garfield Weston Foundation have launched a new grant program to inspire scientists to envision research projects that will use existing data and/or biological samples from PPMI and another large-scale biomarker study, the Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Learn More