Welcome to the Parkinson’s Progression Markers Initiative (PPMI), a landmark observational clinical study to comprehensively evaluate cohorts of significant interest using advanced imaging, biologic sampling and clinical and behavioral assessments to identify biomarkers of Parkinson’s disease progression.
PPMI is taking place at clinical sites in the United States, Europe, Israel, and Australia. Data and samples acquired from study participants will enable the development of a comprehensive Parkinson’s database and biorepository, which is currently available to the scientific community to conduct field-changing research.
PPMI is made possible by the concerted efforts of a number of collaborators. This study is sponsored by The Michael J. Fox Foundation for Parkinson’s Research.
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A recent publication in the journal Parkinsonism and Related Disorders used PPMI data to find that more severe daytime sleepiness and fatigue are associated with greater cognitive impairment. The study’s researchers used PPMI data as well as data from two other studies in order to examine this relationship across the different stages of Parkinson’s.
The first longitudinal findings from PPMI have been published. Researchers from the University of Pennsylvania affiliated with PPMI published in the journal Neurology that depression, anxiety and fatigue are more common in newly diagnosed Parkinson’s disease patients compared to the general population.
The PPMI study cores are responsible for a wide range of study needs including analyzing, storing, and performing quality control measures on the study data and specimens, providing supplies, guidance, and support to study sites, and performance and study management. In this core spotlight, Genetics Coordination Core Principal Investigator Tatiana Foroud, PhD and her team explain their role in PPMI.
The Widespread Recruitment Initiative (WRI) is an internet-based recruitment tool that allows potential PPMI participants to be screened, consented and provided with LRRK2 testing without having to visit a PPMI site. Find out how the process works.
New research from Johns Hopkins University using PPMI baseline data from Parkinson’s patients has found that those experiencing REM sleep behavior disorder (RBD) symptoms have more severe motor symptoms than patients without RBD. The findings were published in the journal Tremor and Other Hyperkinetic Movements.