Our Mission

The mission of PPMI is to identify one or more biomarkers of Parkinson’s disease progression. The discovery of a biomarker is a critical step in the development of new and better treatments for PD. This study is being sponsored by The Michael J. Fox Foundation for Parkinson's Research.

PPMI Enrollment Status

Prodromal Participants
Enrollment Goal: 100

Genetic Cohort Participants
Enrollmen Goal: 600

Genetic Registry Participants
Enrollment Goal: ~600

De Novo PD Participants
Enrollment Goal: 400

Control Participants
Enrollment Goal: 200

Subjects with SWEDD
Enrollment: 64

Last Update: October 14, 2014


More about study cohorts >


Welcome to the Parkinson’s Progression Markers Initiative (PPMI), a landmark observational clinical study to comprehensively evaluate cohorts of significant interest using advanced imaging, biologic sampling and clinical and behavioral assessments to identify biomarkers of Parkinson’s disease progression.

PPMI is taking place at clinical sites in the United States, Europe, Israel, and Australia. Data and samples acquired from study participants will enable the development of a comprehensive Parkinson’s database and biorepository, which is currently available to the scientific community to conduct field-changing research.

PPMI is made possible by the concerted efforts of a number of collaborators. This study is sponsored by The Michael J. Fox Foundation for Parkinson’s Research.

Learn more about Who We Are.


PPMI Presentation at the Parkinson’s Disease Therapeutics Conference 10/29

PPMI’s principal investigator, Dr. Ken Marek, will present on the initial findings of PPMI at the 8th Annual Parkinson’s Disease Therapeutics Conference on October 29 in New York City.

Participant Study Update Call on PPMI Imaging

The audio from the latest PPMI Participant Study Update Call has just been posted. On the call, the principal investigator of the PPMI Imaging Core, John Seibyl, MD of Molecular Neuroimaging, LLC, discusses the role of imaging in PPMI. Listen to this call and find an archive of the past calls here.

New Publication on SPECT Imaging and Executive Function

A new study using PPMI data was published in the journal Movement Disorders exploring the relationship between cognitive impairment and dopaminergic deficits in unmedicated Parkinson’s patients.

PPMI Protocol Updated

PPMI was designed to be adaptable to changing needs, targets, and opportunities in research. In reflection of this, PPMI recently updated its study protocol to include new and revised procedures and assessments. View a summary of the latest changes.

Daytime Sleepiness and Fatigue Associated with Cognitive Impairment

A recent publication in the journal Parkinsonism and Related Disorders used PPMI data to find that more severe daytime sleepiness and fatigue are associated with greater cognitive impairment. The study’s researchers used PPMI data as well as data from two other studies in order to examine this relationship across the different stages of Parkinson’s.

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