Tag Archive | "For Prospective Participants"

Diffusion Tensor Imaging Reflects Degree of Motor Symptoms

In a recent publication in Movement Disorders, Zhang, et al. used PPMI data and found that diffusion tensor imaging (DTI) detected neural fiber abnormalities in people with Parkinson's disease (PD) and that the degree of deviation from normal neural fiber integrity is associated with the severity of motor symptoms in patients.

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SWEDDs and Nonmotor Symptoms Publication

In a recent paper in Movement Disorders, researchers sought to better understand SWEDDs compared to people with Parkinson's and healthy controls (HCs) by comparing the nonmotor symptoms for each group using the PPMI baseline data. Certain symptoms, like orthostatic hypotension, were found to be more common in SWEDDs than in PD participants.

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Results Published on Cognitive Performance and Neuropsychatric Symptoms

In a paper published in Movement Disorders, Weintraub, et al. investigate the prevalence of cognitive impairment and neuropsychiatric symptoms (NPS), such as depression, apathy, and anxiety, in early, unmedicated people with Parkinson's compared with healthy controls (HCs) using the PPMI baseline data.

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Reform Movement and The Michael J. Fox Foundation Team Up for Study Investigating Genetic Mutations Common in Jews

Religious Action Center of Reform Judaism Director Rabbi Jonah Pesner: ?This study provides an important opportunity to help potentially stamp out an insidious disease and reflects the Jewish imperative toward pikuach nefesh, the saving of a life.?

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PPMI Expands to Include Individuals with GBA Mutation

PPMI will now be following individuals with a GBA mutation as part of the Genetic Cohort. In addition to being linked to Parkinson's disease, GBA mutations can cause Gaucher disease. A GBA mutation is more common among certain populations, specifically those of Ashkenazi (Eastern European) Jewish descent. Read the full press release here.

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Video: Thank you from Michael J. Fox

Michael J. Fox has created an exclusive video thanking the PPMI volunteers and researchers for their exceptional contributions to Parkinson's research.

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New Publication on SPECT Imaging and Executive Function

A new study using PPMI data was published in the journal Movement Disorders exploring the relationship between cognitive impairment and dopaminergic deficits in unmedicated Parkinson's patients.

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First Longitudinal Findings: Psychiatric Symptoms More Common in Untreated PD Patients than Controls

The first longitudinal findings from PPMI have been published. Researchers from the University of Pennsylvania affiliated with PPMI published in the journal Neurology that depression, anxiety and fatigue are more common in newly diagnosed Parkinson?s disease patients compared to the general population.

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Core Focus: the Genetics Coordination Core

The PPMI study cores are responsible for a wide range of study needs including analyzing, storing, and performing quality control measures on the study data and specimens, providing supplies, guidance, and support to study sites, and performance and study management. In this core spotlight, Genetics Coordination Core Principal Investigator Tatiana Foroud, PhD and her team explain their role in PPMI.

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Understanding the Genetic Widespread Recruitment Initiative

The Widespread Recruitment Initiative (WRI) is an internet-based recruitment tool that allows potential PPMI participants to be screened, consented and provided with LRRK2 testing without having to visit a PPMI site. Find out how the process works.

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