Tag Archive | "For Enrolled Participants"

Diffusion Tensor Imaging Reflects Degree of Motor Symptoms

In a recent publication in Movement Disorders, Zhang, et al. used PPMI data and found that diffusion tensor imaging (DTI) detected neural fiber abnormalities in people with Parkinson's disease (PD) and that the degree of deviation from normal neural fiber integrity is associated with the severity of motor symptoms in patients.

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PPMI Participating in Upcoming Datathon

The tranSMART Foundation is hosting the Cross Neurodegenerative Diseases Datathon June 30 - July 2. Scientists will use the tranSMART Platform to perform analyses across multiple public datasets in the neurodegenerative disease field, including PPMI, BioFIND, LRRK2, ADNI, and GEO PD.

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Biospecimen Analysis Call for Participants Posted

Dr. Mollenhauer: "[Cerebrospinal fluid] bears the possibility to reflect the underlying biology of the disease process." Find out what makes the PPMI biospecimens, like cerebrospinal fluid, so important to finding progression markers for PD.

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Morphological Changes in the PD Brain

Frontiers in Neuroscience recently published an article by Garg, et al. comparing changes in the volume of different regions of the brain between healthy controls and people with Parkinson's using structural MRIs from PPMI and the University of British Columbia.

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AD/PD & AAN Presentations Posted

With the PPMI data set and biospecimen sample inventory rapidly growing, PPMI data is increasingly being presented around the globe. View some highlights of PPMI data presentations from this past season.

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SWEDDs and Nonmotor Symptoms Publication

In a recent paper in Movement Disorders, researchers sought to better understand SWEDDs compared to people with Parkinson's and healthy controls (HCs) by comparing the nonmotor symptoms for each group using the PPMI baseline data. Certain symptoms, like orthostatic hypotension, were found to be more common in SWEDDs than in PD participants.

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Results Published on Cognitive Performance and Neuropsychatric Symptoms

In a paper published in Movement Disorders, Weintraub, et al. investigate the prevalence of cognitive impairment and neuropsychiatric symptoms (NPS), such as depression, apathy, and anxiety, in early, unmedicated people with Parkinson's compared with healthy controls (HCs) using the PPMI baseline data.

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Dr. Ken Marek’s Presentation for Enrolled Participants Posted

PPMI Principal Investigator, Dr. Ken Marek: "We have made a great deal of progress in the study, largely thanks to the persistence of the sites, of the investigators, and, most importantly, of the participants." Listen to Marek's full presentation.

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Reform Movement and The Michael J. Fox Foundation Team Up for Study Investigating Genetic Mutations Common in Jews

Religious Action Center of Reform Judaism Director Rabbi Jonah Pesner: ?This study provides an important opportunity to help potentially stamp out an insidious disease and reflects the Jewish imperative toward pikuach nefesh, the saving of a life.?

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PPMI Expands to Include Individuals with GBA Mutation

PPMI will now be following individuals with a GBA mutation as part of the Genetic Cohort. In addition to being linked to Parkinson's disease, GBA mutations can cause Gaucher disease. A GBA mutation is more common among certain populations, specifically those of Ashkenazi (Eastern European) Jewish descent. Read the full press release here.

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