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Objective Measurement of Upper Extremity Motor Function in de novo Parkinson's Disease

Chahine, L; Uribe, L; Hogarth, P; Jennings, D; The Parkinson\'s Progression Markers Initiative
AAN: Washington, DC
Download Presentation: Chahine-poster-AAN-2015.pdf
OBJECTIVES: To assess the following characteristics of the ?Objective Parkinson's Disease Measurement? (OPDM) system in quantitating upper extremity motor function in Parkinson's Disease (PD) (i) validity relative to examiner-based measures (ii) sensitivity to change and (iii) predictive value

BACKGROUND: In PD, standardized, physician-administered scales of motor assessment are well validated and widely adopted, but objective measures of motor function are needed. Portable measures, administrable outside of the clinical setting, would be valuable for out-of-office assessments. Technology-based tools have great potential in this regard.

METHODS: De novo PD subjects participating in this pilot study of the Parkinson Progression Markers Initiative (PPMI) completed OPDM assessments at baseline and 3, 6, and 12 months of follow-up including (i) digitography (measured by keyboard downward stroke velocity) (ii) a repetitive hand tapping task and (iii) timed pegboard task. A global objective motor score (OMS) was derived from the latter three. MDS-UPDRS III score and H&Y staging were obtained at each time point. All results shown are adjusted for age, gender, and disease duration.

RESULTS: 27 subjects, mean age 62.6 (range: 37-85) years, 19 (70.4%) male, participated in the baseline visit, and 24 in the 12 month visit. Mean baseline MDS-UPDRS III score was 21.0 (SD 7.67). In univariate analysis, mean OMS correlated with baseline MDS-UPRS III scores (?=0.658, p=<0.0001). Baseline OMS predicted 12 month MDS-UPRS III (? = 0.563, p=0.0027) but not change in MDS-UPRS III score.

CONCLUSIONS: The OPDM device may be a useful tool to objectively assess motor function in PD.