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Neurobehavioral Disorders In Parkinsonian Patients Without Dopamine Deficits (SWEDD)

Amin Demerdash, MBBCh; Kenneth M Heilman, MD, FAAN; Joanna Myers; Chase Mitchell, BS; David Standaert, MD,PhD, FAAN; Frank Skidmore, MD
Philadelphia, PA
Download Presentation: SWEDD Poster AAN Meeting.pdf
OBJECTIVE: To learn if SWEDD patients have different neurobehavioral disorders than do those patients with Parkinson?s disease (PD) who have evidence for a presynaptic dopamine deficit (PDDD) and healthy controls.BACKGROUND A portion of patients who meet the Brain Bank Criteria for Parkinson?s disease (PD), when imaged with photon emission computed tomography have no evidence of presynaptic dopaminergic deficit (SWEDD).
DESIGN/METHODS: The participants were 417 patients from the Parkinson Progression Marker Initiative (PPMI), who were divided into those with SWEDD (n=57), PD (n=178) and healthy controls (n=182). Cognitive functions and mood disorders were studied using Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale (GDS).
RESULTS: MoCA score mean was lower in SWEDDs than PDs (p=0.045) and healthy controls (p=0.002). Depression score mean was not different between SWEDDs and PDs (P=0.2), but both were higher than healthy controls.
CONCLUSIONS: The patients with SWEDD have a greater cognitive impairment than do those with PD and controls. Future studies will have to determine the cause for this cognitive decline.