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REM Sleep And Motor Symptoms In Parkinson's Disease: A Cross Sectional Analysis

Mahajan, A; Rosenthal, L; Gamaldo, C; Salas, R. M; Pontone, G; McCoy, A; Gulyani, S; Umeh, C; Mari, Z
 
2014-04-29
AAN: Philadelphia, PA
Download Presentation: AAN REM-sleep-behavior-and-motor-symptoms-in-Parkinsons.pdf
 
Abstract:
OBJECTIVE:
To evaluate the relationship between Rapid Eye Movement Sleep Behavioral Disorder (RBD) and motor symptoms of de novo Parkinson disease.

BACKGROUND:
Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging populations. While symptomatic therapy is available, disease prevention remains a top priority. Understanding the connection between PD and its prodromal conditions, often predating the appearance of motor symptoms by years, is critical to ongoing research efforts to identify prevention strategies. Rapid Eye Movement Sleep Behavioral Disorder (RBD) is an established risk factor for PD, but its relationship with the severity of motor symptoms in early PD is unknown. This study aims to examine that relationship.

DESIGN/METHODS:
The study population consisted of 418 PD patients who completed the Movement Disorders Society - United Parkinson's Disease Rating Scale (MDS-UPDRS) and Rapid Eye Movement Sleep (REM) Disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross sectional analysis was carried out to assess the association between REM sleep scores and MDS UPDRS-3 (motor) score categories. A score of 5 on the REM disorder questionnaire was defined as symptomatic for RBD.

RESULTS:
Out of the 418 PD patients, 113 (27.03%) had RBD. In univariate analysis, Individuals with RBD were 1.66 times more likely to have worse motor symptoms. (p = 0.028).

CONCLUSIONS:
RBD was associated with worse motor symptoms in PD patients. This association furthers our understanding of the relationship between RBD and motor manifestations in PD.

Study Supported by:
Michael J. Fox Foundation