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Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson's Disease

Soufiane Boucetta, Ali Salimi, Mahsa Dadar, Barbara E. Jones, D. Louis Collins & Thien Thanh Dang-Vu
 
2016-06-01
http://www.nature.com/articles/srep26782
Download Presentation: Boucetta-S.-et-al.2016.pdf
 
Abstract:
Characterized by dream-enactment motor manifestations arising from rapid eye movement (REM) sleep, REM sleep behavior disorder (RBD) is frequently encountered in Parkinson's disease (PD). Yet the specific neurostructural changes associated with RBD in PD patients remain to be revealed by neuroimaging. Here we identified such neurostructural alterations by comparing large samples of magnetic resonance imaging (MRI) scans in 69 PD patients with probable RBD, 240 patients without RBD and 138 healthy controls, using deformation-based morphometry (p?