The PPMI News page provides updates on the latest PPMI developments, including information on the progress of PD biomarker research, scientific publications and presentations, clinical site and recruitment news, as well as articles in the media that feature the study. Sign up for email updates to be notified when new posts are added.

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Recent Posts

Researchers identify biomarker for early cognitive decline in Parkinson’s disease patients using PPMI data

Feb 25, 2016

Many patients with Parkinson?s Disease (PD) develop mild cognitive impairment (MCI) or dementia. Identifying biomarkers for cognitive impairment could be instrumental in facilitating both early diagnosis of MCI and developing new cognitive-enhancing treatments. New research using PPMI data published in the Journal of Parkinson?s Disease indicates that lower concentrations of ?-synuclein in cerebrospinal fluid (CSF) is associated with reduced performance on several cognitive tests.

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Dr. Omar El-Agnaf to use PPMI biospecimens for validation of cerebral spinal fluid ?-synuclein species as surrogate biomarkers for Parkinson?s disease

Feb 15, 2016

We are excited to announce another recent approval by our Biospecimen Review Committee. Dr. Omar El-Agnaf, Professor at Hamad Bin Khalifa University in Doha, Qatar, will be using PPMI biospecimens for a project entitled: Validation of CSF ?-synuclein species as surrogate biomarkers for Parkinson?s disease. Dr. El-Agnaf has recently reported higher levels of the oligomeric […]

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Dr. Martin Rabey to use PPMI biospecimens for validation of a blood based gene expression assay

Feb 1, 2016

A critical component of PPMI is the standardized, longitudinal collection of biospecimens. Each month the Biospecimen Review Committee examines requests for biospecimens collected through the PPMI study. We are excited to announce approval for Dr. Martin Rabey, the Chief Medical Officer of BioShai Ltd, for a project entitled: Validation of a blood based gene expression […]

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Update to PPMI Protocol

Jan 8, 2016

PPMI?s updated study protocol (version 11.0) allows for subjects enrolled in the Parkinson?s Disease (PD) and Healthy Control cohorts to continue participation in PPMI beyond month 60.  Subjects in these two cohorts consenting to amendment 10 will be followed through month 96 (V15). Subjects in the PD cohort will continue with annual in person visits […]

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Diffusion Tensor Imaging Reflects Degree of Motor Symptoms

Jul 13, 2015

In a recent publication in Movement Disorders, Zhang, et al. used PPMI data and found that diffusion tensor imaging (DTI) detected neural fiber abnormalities in people with Parkinson's disease (PD) and that the degree of deviation from normal neural fiber integrity is associated with the severity of motor symptoms in patients.

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PPMI Participating in Upcoming Datathon

Jun 23, 2015

The tranSMART Foundation is hosting the Cross Neurodegenerative Diseases Datathon June 30 - July 2. Scientists will use the tranSMART Platform to perform analyses across multiple public datasets in the neurodegenerative disease field, including PPMI, BioFIND, LRRK2, ADNI, and GEO PD.

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Biospecimen Analysis Call for Participants Posted

Jun 22, 2015

Dr. Mollenhauer: "[Cerebrospinal fluid] bears the possibility to reflect the underlying biology of the disease process." Find out what makes the PPMI biospecimens, like cerebrospinal fluid, so important to finding progression markers for PD.

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New Feature: Subject Visit Tables

Jun 17, 2015

The Study Cohorts page has been updated to give researchers a view of the visit data available for each cohort.

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PPMI at MDS 2015

Jun 12, 2015

PPMI is excited to announce that several presentations at the 19th International Congress of Parkinson's Disease and Movement Disorders (MDS) will feature PPMI data. View the PPMI-related abstracts for this congress happening in San Diego, California on June 14-18.

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PPMI Annual Meeting 2015 Summary

Jun 11, 2015

Nearly 150 PPMI investigators, coordinators, study cores, patient advisory and steering committee members, sponsors, and industry partners from around the world met in New York City May 13-14, 2015 to share PPMI updates and to discuss the future of the initiative. View the meeting's presentations.

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