PPMI RNA Sequencing Project

Background

The Parkinson’s Progression Markers Initiative (PPMI) is a longitudinal observational study sponsored by The Michael J. Fox Foundation for Parkinson’s Research. PPMI collects, generates, compares and makes available high-quality research data to better define, measure and treat Parkinson’s disease (PD). Cohorts include idiopathic and genetic PD as well as individuals with clinical and genetic risk factors and control volunteers. A more comprehensive overview of PPMI aims, cohorts and protocols is at www.ppmi-info.org.

RNA Sequencing Portal

The PPMI RNA Sequencing Project has developed a single platform providing overviews of transcriptomic data generated from raw sequencing reads of PPMI samples. Researchers can survey the data without the need to download or manipulate raw data.

Primary functionality focuses on understanding gene expression levels, single-transcript localization and quality metrics for each sample. This tool allows users to observe changes in gene expression for each gene transcript present in the human genome, including distinction across cohorts and disease states. This allows for rapid survey of genes of interest, supporting detailed analysis and hypothesis testing. Raw (FASTQ + BAM) sequencing files for reanalysis are available upon request.

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