Study Goals


The mission of PPMI is to identify one or more biomarkers of Parkinson’s disease (PD) progression, a critical next step in the development of new and better treatments for PD. PPMI will establish a comprehensive, standardized, longitudinal PD data and biological sample repository that will be made available to the research community.

Study Aims

PPMI is an observational, multi-center study that will collect clinical and imaging data and biologic samples from various cohorts, that can be used by scientists to establish markers of disease progression in PD.

Specific aims to accomplish this objective include:

  1. Develop a comprehensive and uniformly acquired clinical/imaging dataset with correlated biological samples that can be used in biomarker verification studies
  2. Establish standardized protocols for acquisition, transfer and analysis of clinical and imaging data and biological samples that can be used by the research community
  3. Investigate existing biomarkers and identify new clinical, imaging and biological markers to determine interval changes in these markers

To learn more about the lead biomarker candidates that have been identified for initial verification studies, click here.