Diffusion Tensor Imaging Reflects Degree of Motor Symptoms

In a recent publication in Movement Disorders, Zhang, et al. showed that diffusion tensor imaging (DTI) detected neural fiber abnormalities in people with Parkinson’s disease (PD) and that the degree of deviation from normal neural fiber integrity is associated with the severity of motor symptoms in patients. This study looked at DTI data from 50 de novo PD participants and 27 healthy control subjects from PPMI.  Using DTI, researchers can visualize the neural fibers in the brain that facilitate dopaminergic function, which is diminished in people with PD.  By demonstrating that DTI could show these abnormalities in PD participants and that those are linked to the severity of motor symptoms, these findings suggest that DTI could potentially be used to diagnose PD and evaluate disease progression.

Read more about this study on PubMed.

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