Morphological Changes in the PD Brain

Frontiers in Neuroscience recently published an article by Garg, et al. comparing changes in the brain’s volume between healthy controls (HC) and people with Parkinson’s (PD).  The study used structural MRIs from PPMI and the University of British Columbia.  Previous studies have examined alterations in brain volume using an overall measure of volume.  Instead of overall volume, this research investigated the volume changes of the caudate, putamen, pallidum, and thalamus separately to account for the possibility of the thalamus increasing in volume as a compensatory mechanism in PD subjects.  Significant differences between HC and PD subjects were found in the caudate and thalamus.

Read the full article on PubMed.

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