Cerebrospinal Fluid Data Posted to PPMI

Dear PPMI community,

Data from the analysis of baseline CSF samples are now available on the PPMI study database. 1,266 CSF samples from all 666 PPMI (PD, Healthy subject, SWEDD) baseline visits and 300 longitudinal visits (6 and 12 month from those subjects who have reached their 12 month visit) have been analyzed for alpha-synuclein (?-SYN), A?1-42, total tau (t-tau), and tau phosphorylated at threonine 181 (p-tau) and data is now available on the PPMI website. These data are listed in the database as projects 110 (CSF A?1-42/t-tau/p-tau) and 111 (CSF ?-SYN).

Be aware  that the mean concentration values for a-SYN and A?1-42 obtained in the 2013 full-study are significantly higher and the p-tau values lower than the mean values obtained in the pilot CSF study (?Pilot Biospecimen Analysis Results Projects 101 and 103??examining a subset of baseline CSF samples, the results of which were published in JAMA Neurology in 2013).  After extensive assessment of pre-analytical and analytical procedures the Steering Committee believes the difference between the full baseline and pilot CSF analyses results are due to assay batch variability between 2011 and 2013 in these research assays. Please refer to the slide deck on the PPMI website entitled ?PPMI CSF baseline analysis_Assay variability_April 2014? for more details.

Should you have any comments or questions regarding this study, please direct them to ppmi@michaeljfox.org.  Thank you for your interest in the PPMI study.

Sincerely,

The PPMI Steering Committee