7:30am ET Saturday and Sunday replay of “Sanjay Gupta MD Reports: A Conversation with Michael J. Fox” on CNN

If you missed the CNN special on Thursday, it will be aired again this weekend. The segment features Sanjay Gupta interviewing Michael J. Fox about his commitment to Parkinson?s research, the work of the Foundation over the past 10 years and where the most promising science is headed. Dr. Bernard Ravina, Principal Investigator of the PPMI Clinical Core, is interviewed about PPMI in the show.

Actor Michael J. Fox talks candidly with CNN’s Dr. Sanjay Gupta about living with Parkinson’s Disease

Michael J. Fox on Parkinson’s and life

By Dr. Sanjay Gupta, CNN Chief Medical Correspondent, CNN

[Click here to watch a short clip of the interview]

When I went to Michael J. Fox?s neighborhood this morning, I had no idea what time we would start our interview. ?He has to time his medications,? I was told. ?When his medications kick in, he will be ready.? As far as I could tell, Fox?s medications kicked in right away, and for the next 90 minutes, we talked about everything.

Fox spoke about the hard shoes he has to wear first thing in the morning, because his feet and legs are so stiff. He humorously added that he just puts his toothbrush in his mouth, and lets the movement of his head do the rest of the work. As a neurosurgeon, it was fascinating to hear Michael describe his own brain surgery with such great clarity and his fears about doing it again. ?Well, it is brain surgery?”  he said with flourish.

There is a lot we don?t know about Parkinson?s disease. For starters, no one is sure what causes it. One?s genetics likely loads the gun, and something in the environment pulls the trigger. But what? It might surprise you to know four people on the set of Fox?s first television series, “Leo and Me,” developed early onset Parkinson?s disease. A statistical anomaly, or a clue? Michael, and his foundation?s scientists aren?t sure. Michael pauses when I ask him about it, he shrugs his shoulders and says, ?I am not as concerned about a few people. I am focused on everyone who has the disease.?

And, to that end, he is putting the $200 million his foundation has raised to work. You won?t hear as much about stem cells from Michael or the foundation, but he will describe in detail the efforts of a five-year, international biomarker study his foundation is funding. The goal is to find more clues about the disease, by collecting samples from patients. It is true that most therapies simply mask the symptoms, and Fox believes that if they find new targets of the disease, it will greatly accelerate the treatments available.

Today, I asked Fox if he was even sure he had Parkinson?s disease. After all, there is no blood test or imaging study. It is just a clinical diagnosis, and Fox’s condition was diagnosed at age 30. He has officially had the disease for nearly two decades. Fox told me he’s pretty sure he has it, but even today Parkinson’s disease is not an exact science.

Michael looked very good today. Good days and bad days, he told me. People think of the natural state of Parkinson’s as the symptoms of stiffness, tremor and lack of facial expression. When Michael is medicated, it is different. He is smiling, passionate and has constant, fluid movements, instead of rigidity. ?Those are the dyskinesias,? he tells me. ?But it buys me time to do the things I want to do,? he added with his characteristic grin. Tomorrow at 8 p.m., you will hear about all the things Michael J. Fox has planned for the future.

Editor’s Note: “Sanjay Gupta MD Reports: A Conversation with Michael J. Fox” airs Thursday at 8 p.m. ET on CNN.

Click here to read the original posting at CNN.com.