Request PBMCs or Cell Lines

Regular longitudinal collection of peripheral mononuclear blood cells (PBMCs) has been integrated into the regular schedule of activities for all PPMI subjects. In addition, PPMI has also expanded to generate fibroblasts and induced pluripotent stem cell (iPSC) lines from a subset of PPMI subjects. The number of available PBMCs is included in the biospecimen inventory catalog that is available through the PPMI database. A separate inventory of the PPMI cell lines is also available through the PPMI database. Unlike PPMI biospecimens, which are reserved for biomarker validation studies, PPMI PBMCs and cell lines may be used for PD biomarker discovery studies. In addition, PPMI cell lines may be used for research in other neurodegenerative disease areas.

Application Process to Request PBMCs or Cell Lines

Researchers interested in requesting PBMCs or cell lines are encouraged to review the Process for Requesting PBMCs or Cell Lines. Researchers requesting PBMCs or cell lines must agree to the PBMC and Cell Lines Use Agreement as well as the Publications Policy. Click the button below to read more about the Process for Requesting PBMCs and Cell Lines and to begin the Request Process.

Go to Cell Line Request Process

Before starting the PBMC and cell line request process, click here to download the application template.

Ongoing Sample Analyses and Other Resources

A listing of preliminary analyses specified by the Steering Committee and performed by PPMI cores, as well as analyses performed by additional investigators will be listed in the Ongoing Analyses section of this site. Investigators who are granted samples from PPMI agree to update this information annually, providing the research public with a comprehensive list of the latest findings coming out of PPMI.

Researchers who are interested in reviewing the PPMI collection, processing and storage protocols for cell lines should review the cell lines manuals in the Research Documents and SOPs section of the PPMI website

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Study Arm FibroblastiPSCsTotal
PD, Control and SWEDD Cell Lines
PD112
Control112
SWEDD11
Study Arm LRRK2+GBA+SNCA+HyposmicRBDTotal
Prodromal and Genetic Cohort IPSCs
Prodromal112
Genetic PD112
Genetic Unaffected1113