March 4th, 2014: IMPORTANT UPDATE REGARDING CSF DATA
To the PPMI community,
As we have completed the baseline assessments of the PPMI PD, healthy subject and SWEDD cohort, we have continued to post quality controlled data on the PPMI website from these subjects as soon as possible. We realize that the CSF data (a-SYN, Aβ1-42, Tau, pTau) from these subjects is highly anticipated so we wanted to make you aware that there will be a delay in our posting the baseline CSF data. These data are undergoing additional quality control. Initial assessment of the CSF data showed a discrepancy from and increased variance in relation to the pilot PPMI data already published in JAMA neurology. Additional studies to assess pre-analytical procedures that may explain this discrepancy are underway. We are committed to making these data available to the PPMI community ASAP and will provide an update on these studies within 2 months.
The PPMI Steering Committee
Accessing PPMI Data & Specimens
A primary goal of PPMI is to develop a large and comprehensive set of correlated clinical data and biospecimens that will be made available to the entire scientific community to help accelerate biomarker verification research. This section of the study site serves as the central hub for academic and industry researchers to download de-identified data and request specimens collected in the study.
PPMI data and specimens have been collected in a standardized manner under strict protocols developed by the steering committee. Click here to review the PPMI Research Documents and SOPs that have been developed to guide PPMI Clinical Sites in data and specimen collection.
PPMI Data: Clinical, Biomarker, Imaging and Related MetaData
The PPMI study dataset includes clinical, biological and imaging data collected at PPMI clinical sites. The data have been aggregated into the PPMI study database, which is managed by the PPMI Bioinformatics Core, the Laboratory of NeuroImaging (LONI) at the University of California, Los Angeles.
For further information about the PPMI database, visit the Data & Specimens FAQ.
PPMI Samples: Biologic Specimens
Biologic specimens collected through PPMI include urine, plasma, serum, cerebrospinal fluid, DNA and RNA. An inventory of collected specimens available for research purposes is available in the PPMI study database. Researchers may apply for access to stored samples, which are housed in the study’s BioRepository at the Coriell Institute for Medical Research.
For further information about the PPMI specimens, visit the Data & Specimens FAQ.
Analysis of PPMI Data and Samples
The PPMI Steering Committee has already identified preliminary analyses that will be conducted on the PPMI data by the study cores. Other investigators are strongly encouraged to access the study data and specimens to conduct their own analyses. To keep the scientific community apprised of analyses being completed by all investigators who are using PPMI data and specimens. A list of Ongoing Analyses has been compiled here.