Access Data & Specimens

May 2nd, 2014: CEREBROSPINAL FLUID DATA POSTED TO PPMI 

Dear PPMI community,

Data from the analysis of baseline CSF samples are now available on the PPMI study database. 1,266 CSF samples from all 666 PPMI (PD, Healthy subject, SWEDD) baseline visits and 300 longitudinal visits (6 and 12 month from those subjects who have reached their 12 month visit) have been analyzed for alpha-synuclein (α-SYN), Aβ1-42, total tau (t-tau), and tau phosphorylated at threonine 181 (p-tau) and data is now available on the PPMI website. These data are listed in the database as projects 110 (CSF Aβ1-42/t-tau/p-tau) and 111 (CSF α-SYN).

Be aware  that the mean concentration values for a-SYN and Aβ1-42 obtained in the 2013 full-study are significantly higher and the p-tau values lower than the mean values obtained in the pilot CSF study (“Pilot Biospecimen Analysis Results Projects 101 and 103”–examining a subset of baseline CSF samples, the results of which were published in JAMA Neurology in 2013).  After extensive assessment of pre-analytical and analytical procedures the Steering Committee believes the difference between the full baseline and pilot CSF analyses results are due to assay batch variability between 2011 and 2013 in these research assays. Please refer to the slide deck on the PPMI website entitled “PPMI CSF baseline analysis_Assay variability_April 2014” for more details.

Should you have any comments or questions regarding this study, please direct them to ppmi@michaeljfox.org.  Thank you for your interest in the PPMI study.

Sincerely,

The PPMI Steering Committee

Accessing PPMI Data & Specimens

A primary goal of PPMI is to develop a large and comprehensive set of correlated clinical data and biospecimens that will be made available to the entire scientific community to help accelerate biomarker verification research. This section of the study site serves as the central hub for academic and industry researchers to download de-identified data and request specimens collected in the study.

PPMI data and specimens have been collected in a standardized manner under strict protocols developed by the steering committee. Click here to review the PPMI Research Documents and SOPs that have been developed to guide PPMI Clinical Sites in data and specimen collection.

PPMI Data: Clinical, Biomarker, Imaging and Related MetaData

The PPMI study dataset includes clinical, biological and imaging data collected at PPMI clinical sites. The data have been aggregated into the PPMI study database, which is managed by the PPMI Bioinformatics Core, the Laboratory of NeuroImaging (LONI) at the University of Southern California.

Download PPMI Data

For further information about the PPMI database, visit the Data & Specimens FAQ.

 

PPMI Samples: Biologic Specimens

Biologic specimens collected through PPMI include urine, plasma, serum, cerebrospinal fluid, DNA and RNA. An inventory of collected specimens available for research purposes is available in the PPMI study database. Researchers may apply for access to stored samples, which are housed in the study’s BioRepository at the Coriell Institute for Medical Research.

Access PPMI Samples

For further information about the PPMI specimens, visit the Data & Specimens FAQ.

 

Analysis of PPMI Data and Samples

The PPMI Steering Committee has already identified preliminary analyses that will be conducted on the PPMI data by the study cores. Other investigators are strongly encouraged to access the study data and specimens to conduct their own analyses. To keep the scientific community apprised of analyses being completed by all investigators who are using PPMI data and specimens. A list of Ongoing Analyses has been compiled here.

• Request Specimens
• Download Data
• Data & Specimens FAQ

Months ScBL369121824303642485460
Biospecimens
CSF66684574212197125
DNA70750741114
RNA666612497545588521376251140444
Plasma684634516566595512363236141474
Serum674633526564599510357232129464
Urine680452160123951685
Whole blood561553475520560504369249159505
Months ScBL122448
PD
MRI140514983
PET16119
SPECT448373167
SWEDD
MRI64218
PET21
SPECT81332
Control
MRI2183669
PET4
SPECT2104