Study Timeline

| 2013 | 2012 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006-2002 |

2013

February 2013: Launch of prodromal cohort to investigate risk factors of PD: hypsomia, REM behavior sleep disorder (RBD), and the presence of a LRRK2 genetic mutation.

April 2013: Enrollment of (400 newly diagnosed and 200 control subjects) completed.

July 2013: First subject enrolled in the Prodromal Cohort of PPMI

September 2013: PPMI Genetics Cohort Kick-Off meeting held in New York, NY

2012

January 2012: 300 of the 600 subjects needed for PPMI are actively enrolled in the study

March 2012: PPMI expands to a third continent—Australia. One site is selected to participate in the study

Spring 2012: PPMI Steering Committee begins discussion of the addition of a new Pre-Motor PD cohort

Fall 2012: PPMI Steering Committee begins planning for the addition of a pre-motor cohort to the study.

2011

March 2011: PPMI-info.org access to study data and specimens becomes available coinciding with 50 subjects having completed baseline visits

August 2011: : PPMI adds a third cohort: Subjects with SWEDD (Scans without Evidence of Dopamanergic Deficit)

2010

January 2010: Steering Committee meeting to finalize Protocol and discuss data flow and SOPs

March 2010: Investigators Meeting brings together members of the steering committee, study cores, clinical sites and MJFF; study protocols, tests and assessment details, recruitment and retention plans and outcomes are discussed

June 2010: PPMI recruitment begins; first PPMI subject is enrolled

2009

June 2009: Protocol Task force is appointed; begins to define study design

August 2009: Steering Committee is formed

September 2009: Study Cores are selected

October 2009: Workshop to further refine core selection, define site selection process and set a timeline for study design and launch; verification study is conducted

2008

May 2008: Workshop to define study objectives, criteria for site selection and other study parameters

2007

February 2007: The Michael J. Fox Foundation (MJFF) Scientific Advisory Board holds a formal discussion on the need for a concerted biomarker effort

June 2007: Workshop to explore feasibility, required  scientific expertise and MJFF’s role in a large-scale biomarkers study

October 2007: Workshop to further define the scientific cores that would be needed to support a large scale biomarkers study

2006-2002

MJFF sponsored three biomarker RFA’s and supported applications exploring clinical, imaging and biochemical biomarkers that would be useful in clinical trials

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